Comparing McDonald's 2 Cheeseburger and Big Mac, both are iconic burgers from the fast-food giant. The 2 Cheeseburger consists of two mini beef patties, American cheese, onions, pickles, and sauce on a sesame seed bun. It's a simple, compact, and budget-friendly option. On the other hand, the Big Mac offers a unique taste with two all-beef patties, special sauce, lettuce, cheese, pickles, and onions on a sesame seed bun with a middle layer of shredded lettuce. The Big Mac's signature sesame seed bun is split into three parts to accommodate the special sauce. Both burgers are popular choices, but the Big Mac's unique flavor profile and additional ingredients set it apart from the more straightforward 2 Cheeseburger.